These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1074-82-4
20ml (1.3X 10 1 mol) 1,6-dibromopentane with 8 g (4.3X 10 2moles) Phthalimide potassium salt dissolved in 100ml of N, N- dimethylformamideand under room temperature it was stirred for 20 hours. The solvent wasdistilled off under reduced pressure The residue using n-hexane: ethyl acetatewith a volume ratio of 10: 1 eluent tocarry out column chromatography, graduallyincreasing the polarity to hexane: ethyl acetate with a volume ratio of 5: 1 togive a product of 9.6g (3.1X102 mole) a bromo group substituted by Phthalimide.The product with 8g (6. 3X 10 2 mol) of sodium sulfite, 160ml waterand 100ml95% ethanol mixed reaction was heated to 100 C for 20h, theremaining solvent was drained, and the resulting residue was mixed with 98ml ofconcentrated hydrochloric acid then was heated to 110 C the for 20H, it was drained,with water – 95% ethanol on the residue to carry out recrystallization to give 3.9g of 6-amino-1-hexylsulfonic acid (totalyield 50%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1074-82-4.
Reference:
Patent; Institute of Chemistry Chinese Academy of Sciences; zhao, jingquan; DENG, HONG; XEI, JIE; (16 pag.)CN101948412; (2016); B;,
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